Molecular weight (DA)
54kD
Immunogen
The antiserum was produced against synthesized peptide derived from human HTR2B. AA range:15-64
Specificity
SR-2B Polyclonal Antibody detects endogenous levels of SR-2B protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016],
Function
function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with MPDZ.,tissue specificity:Detected in most peripheral organs. Only low expression levels were found in the brain.,
Protein name
5-hydroxytryptamine receptor 2B
Other name
HTR2B; 5-hydroxytryptamine receptor 2B; 5-HT-2B; 5-HT2B; Serotonin receptor 2B
Fields
>>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction;>>Gap junction;>>Serotonergic synapse;>>Inflammatory mediator regulation of TRP channels
Human protein sequence Database
P41595
Mouse protein sequence database
Q02152
Rat protein sequence database
Cellular localization
Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, synaptosome .
Tissue expression
Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex.
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