Molecular weight (DA)
42kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Pepsin A. AA range:258-307
Specificity
Pepsin A Polyclonal Antibody detects endogenous levels of Pepsin A protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015],
Function
catalytic activity:Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves 1-Phe-|-Val-2, 4-Gln-|-His-5, 13-Glu-|-Ala-14, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17, 23-Gly-|-Phe-24, 24-Phe-|-Phe-25 and 25-Phe-|-Tyr-26 bonds in the B chain of insulin.,function:Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.,similarity:Belongs to the peptidase A1 family.,
Other name
Pepsin A; PGA3; PGA4; PGA5
Human gene ID
5222/643847
Human protein sequence Database
P00790
Mouse protein sequence database
Rat protein sequence database
Cellular localization
extracellular exosome,multivesicular body lumen,
Tissue expression
Brain,Colon,Kidney,Placenta,Skeletal muscle,
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