Molecular weight (DA)
60kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Cytochrome P450 4A11/22. AA range:391-440
Specificity
CYP4A11/22 Polyclonal Antibody detects endogenous levels of CYP4A11/22 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
cytochrome P450 family 4 subfamily A member 11(CYP4A11) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016],
Function
catalytic activity:Octane + reduced rubredoxin + O(2) = 1-octanol + oxidized rubredoxin + H(2)O.,cofactor:Heme group.,function:Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).,online information:CYP4A11 alleles,polymorphism:CYP4A11v seems to be a rare allelic variant of CYP4A11, it seems to be unstable and not to metabolize lauric acid.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Kidney and liver.,
Gene Name
CYP4A11/CYP4A22
Protein name
Cytochrome P450 4A11/22
Other name
CYP4A11; CYP4A2; Cytochrome P450 4A11; 20-hydroxyeicosatetraenoic acid synthase; 20-HETE synthase; CYP4AII; CYPIVA11; Cytochrome P-450HK-omega; Cytochrome P450HL-omega; Fatty acid omega-hydroxylase; Lauric acid omega-hydroxylase; CYP4A22; C
Human gene ID
1579/284541
Human protein sequence Database
Q02928/Q5TCH4
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane ; Peripheral membrane protein . Microsome membrane ; Peripheral membrane protein .
Tissue expression
Expressed in liver (PubMed:7679927). Expressed in S2 and S3 segments of proximal tubules in cortex and outer medulla of kidney (PubMed:7679927, PubMed:10660572).
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