Molecular weight (DA)
60kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Cytochrome P450 2C8/9/18/19. AA range:111-160
Specificity
CYP2C8/9/18/19 Polyclonal Antibody detects endogenous levels of CYP2C8/9/18/19 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010],
Function
catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,caution:Alternative splicing has been shown to occur but the shorter forms are believed to be non-functional.,cofactor:Heme group.,function:Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).,induction:By phenobarbital.,online information:CYP2C8 alleles,similarity:Belongs to the cytochrome P450 family.,
Protein name
Cytochrome P450 2C8/9/18/19
Abbreviation
CYP2C8/9/18/19
Other name
CYP2C8; Cytochrome P450 2C8; CYPIIC8; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 form 1; S-mephenytoin 4-hydroxylase; CYP2C9; CYP2C10; Cytochrome P450 2C9; (R)-limonene 6-monooxygenase; (S)-limonene
Fields
>>Arachidonic acid metabolism;>>Linoleic acid metabolism;>>Retinol metabolism;>>Drug metabolism - cytochrome P450;>>Metabolic pathways;>>Serotonergic synapse;>>Chemical carcinogenesis - DNA adducts;>>Lipid and atherosclerosis
Human gene ID
1562/1558/1559/1557
Human protein sequence Database
P10632/P11712/P33260/P33261
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue expression
Blood,Kidney,Liver,
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