Molecular weight (DA)
80kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CAPN12. AA range:221-270
Specificity
Calpain 12 Polyclonal Antibody detects endogenous levels of Calpain 12 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes a member of the calpain large subunit family. [provided by RefSeq, Jun 2012],
Function
catalytic activity:Broad endopeptidase specificity.,function:Calcium-regulated non-lysosomal thiol-protease.,similarity:Belongs to the peptidase C2 family.,similarity:Contains 1 calpain catalytic domain.,similarity:Contains 1 EF-hand domain.,
Other name
CAPN12; Calpain-12; Calcium-activated neutral proteinase 12; CANP 12
Human protein sequence Database
Q6ZSI9
Mouse protein sequence database
Q9ER56
Rat protein sequence database
Cellular localization
intracellular,cytoplasm,
Tissue expression
Thalamus,
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