Molecular weight (DA)
38kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CA3. AA range:141-190
Specificity
CA III Polyclonal Antibody detects endogenous levels of CA III protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. The gene spans 10.3 kb and contains seven exons and six introns. [provided by RefSeq, Oct 2008],
Function
catalytic activity:H(2)CO(3) = CO(2) + H(2)O.,cofactor:Zinc.,developmental stage:At 6 weeks gestation, transcripts accumulate at low levels in the somites and at high levels throughout the notochord. As gestation continues, CA3 becomes abundant in all developing muscle masses and continues at high to moderate levels in the notochord.,function:Reversible hydration of carbon dioxide.,similarity:Belongs to the alpha-carbonic anhydrase family.,tissue specificity:Muscle specific.,
Protein name
Carbonic anhydrase 3
Other name
CA3; Carbonic anhydrase 3; Carbonate dehydratase III; Carbonic anhydrase III; CA-III
Fields
>>Nitrogen metabolism;>>Metabolic pathways
Human protein sequence Database
P07451
Mouse protein sequence database
P16015
Rat protein sequence database
P14141
Cellular localization
Cytoplasm .
Tissue expression
Muscle specific.
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