Molecular weight (DA)
75kD
Immunogen
The antiserum was produced against synthesized peptide derived from the C-terminal region of human FOXP1. AA range:628-677
Specificity
FOXP1 Polyclonal Antibody detects endogenous levels of FOXP1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Function
alternative products:Additional isoforms seem to exist,disease:A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. Translocation t(9;3)(p13;p14.1) with PAX5.,domain:The leucine-zipper is required for dimerization and transcriptional repression.,function:Transcriptional repressor that plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B cell development.,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 fork-head DNA-binding domain.,subunit:Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1.,
Protein name
Forkhead box protein P1
Other name
FOXP1; HSPC215; Forkhead box protein P1
Fields
>>MicroRNAs in cancer
Human protein sequence Database
Q9H334
Mouse protein sequence database
P58462
Rat protein sequence database
Q498D1
Cellular localization
Nucleus . Not found in the nucleolus. .
Tissue expression
Isoform 8 is specifically expressed in embryonic stem cells.
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