Molecular weight (DA)
44kD
Immunogen
Synthesized peptide derived from the Internal region of human KLF12.
Specificity
KLF12 Polyclonal Antibody detects endogenous levels of KLF12 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
function:Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.,similarity:Belongs to the Sp1 C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,
Protein name
Krueppel-like factor 12
Other name
KLF12; AP2REP; HSPC122; Krueppel-like factor 12; Transcriptional repressor AP-2rep
Human protein sequence Database
Q9Y4X4
Mouse protein sequence database
O35738
Rat protein sequence database
Cellular localization
Nucleus.
Tissue expression
Brain,Hypothalamus,Umbilical cord blood,
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