Molecular weight (DA)
16kD
Immunogen
The antiserum was produced against synthesized peptide derived from human TSC22D1. AA range:71-120
Specificity
TSC-22 Polyclonal Antibody detects endogenous levels of TSC-22 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011],
Function
function:Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter.,induction:In aortic endothelial cells, induced by cytokines, including TGFB.,similarity:Belongs to the TSC-22/Dip/Bun family.,subunit:Homodimer or heterodimer. Can form an heterodimer with TSC22D4.,tissue specificity:Widely expressed in fetal and adult tissues.,
Protein name
TSC22 domain family protein 1
Other name
TSC22D1; KIAA1994; TGFB1I4; TSC22; hucep-2; TSC22 domain family protein 1; Cerebral protein 2; Regulatory protein TSC-22; TGFB-stimulated clone 22 homolog; Transforming growth factor beta-1-induced transcript 4 protein
Human protein sequence Database
Q15714
Mouse protein sequence database
P62500
Rat protein sequence database
P62501
Cellular localization
Cytoplasm . Nucleus .
Tissue expression
Widely expressed in fetal and adult tissues.
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