Molecular weight (DA)
54kD
Immunogen
Synthesized peptide derived from DNA Pol μ . at AA range: 210-290
Specificity
DNA Pol μ Polyclonal Antibody detects endogenous levels of DNA Pol μ protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,cofactor:Magnesium.,function:Seems to act as an Ig mutase which is responsible for immunoglobulin (Ig) gene hypermutation.,similarity:Belongs to the DNA polymerase type-X family.,similarity:Contains 1 BRCT domain.,tissue specificity:Expressed in a number of tissues. Abundant in thymus.,
Function
catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,cofactor:Magnesium.,function:Seems to act as an Ig mutase which is responsible for immunoglobulin (Ig) gene hypermutation.,similarity:Belongs to the DNA polymerase type-X family.,similarity:Contains 1 BRCT domain.,tissue specificity:Expressed in a number of tissues. Abundant in thymus.,
Protein name
DNA-directed DNA/RNA polymerase mu
Other name
POLM; polmu; DNA-directed DNA/RNA polymerase mu; Pol Mu; Terminal transferase
Fields
>>Non-homologous end-joining
Human protein sequence Database
Q9NP87
Mouse protein sequence database
Q9JIW4
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Expressed in a number of tissues. Abundant in thymus.
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