Molecular weight (DA)
50kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ZFYVE19. AA range:311-360
Specificity
ZFYVE19 Polyclonal Antibody detects endogenous levels of ZFYVE19 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
disease:A chromosomal aberration involving ZFYVE19 is associated with acute myeloblastic leukemia (AML). Translocation t(11;15)(q23;q14) with MLL/HRX.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 FYVE-type zinc finger.,tissue specificity:Detected in brain, heart, skeletal muscle, kidney and liver.,
Function
disease:A chromosomal aberration involving ZFYVE19 is associated with acute myeloblastic leukemia (AML). Translocation t(11;15)(q23;q14) with MLL/HRX.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 FYVE-type zinc finger.,tissue specificity:Detected in brain, heart, skeletal muscle, kidney and liver.,
Protein name
Zinc finger FYVE domain-containing protein 19
Other name
ZFYVE19; MPFYVE; Zinc finger FYVE domain-containing protein 19; MLL partner containing FYVE domain
Human protein sequence Database
Q96K21
Mouse protein sequence database
Q9DAZ9
Rat protein sequence database
Cellular localization
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cleavage furrow . Midbody, Midbody ring . Localizes mainly on centrosomes in interphase and early mitosis. Localizes at the cleavage furrow and midbody ring in late mitosis and cytokinesis. .
Tissue expression
Detected in brain, heart, skeletal muscle, kidney and liver.
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