Molecular weight (DA)
57kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 320-400
Specificity
VNN2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011],
Function
function:Probable hydrolase. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.,similarity:Belongs to the CN hydrolase family. BTD/VNN subfamily.,similarity:Contains 1 CN hydrolase domain.,tissue specificity:Expressed in spleen, thymus, peripheral blood lymphocytes and kidney.,
Protein name
Vascular non-inflammatory molecule 2 (Vanin-2) (EC 3.5.1.92) (Glycosylphosphatidyl inositol-anchored protein GPI-80) (Protein FOAP-4)
Fields
>>Pantothenate and CoA biosynthesis;>>Metabolic pathways
Human protein sequence Database
O95498
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cell membrane ; Lipid-anchor, GPI-anchor .
Tissue expression
Widely expressed with higher expression in spleen and blood.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车