Molecular weight (DA)
105kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SFRS8. AA range:201-250
Specificity
SWAP Polyclonal Antibody detects endogenous levels of SWAP protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a human homolog of Drosophila splicing regulatory protein. This gene autoregulates its expression by control of splicing of its first two introns. In addition, it also regulates the splicing of fibronectin and CD45 genes. Two transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2012],
Function
function:May function as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 2 SURP motif repeats.,
Protein name
Splicing factor suppressor of white-apricot homolog
Other name
SFSWAP; SFRS8; SWAP; Splicing factor; suppressor of white-apricot homolog; Splicing factor, arginine/serine-rich 8; Suppressor of white apricot protein homolog
Human protein sequence Database
Q12872
Mouse protein sequence database
Q3USH5
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Brain,Epithelium,Eye,Placenta,Skin,
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