Molecular weight (DA)
25kD
Immunogen
The antiserum was produced against synthesized peptide derived from human 60S Ribosomal Protein L10. AA range:1-50
Specificity
QM Polyclonal Antibody detects endogenous levels of QM protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015],
Function
developmental stage:Down-regulated during adipocyte, kidney, and heart differentiation.,disease:Defects in RPL10 may be the cause of susceptibility to X-linked autism [MIM:209850]. Autism is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age.,similarity:Belongs to the ribosomal protein L10e family.,
Protein name
60S ribosomal protein L10
Other name
RPL10; DXS648E; QM; 60S ribosomal protein L10; Laminin receptor homolog; Protein QM; Tumor suppressor QM
Fields
>>Ribosome;>>Coronavirus disease - COVID-19
Human protein sequence Database
P27635
Mouse protein sequence database
Q6ZWV3
Rat protein sequence database
Q6PDV7
Cellular localization
endoplasmic reticulum,cytosol,ribosome,membrane,cytosolic large ribosomal subunit,
Tissue expression
Brain,Human lung,Mammary cancer,Mammary gland,Ovarian carcinoma,Pancreatic cancer,P
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