Immunogen
The antiserum was produced against synthesized peptide derived from human NUCKS1. AA range:28-77
Specificity
NUCKS Polyclonal Antibody detects endogenous levels of NUCKS protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle. [provided by RefSeq, Aug 2010],
Function
PTM:Phosphorylated by CDK1 and casein kinase. Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Translated as Arg.,
Protein name
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
Other name
NUCKS1; NUCKS; JC7; Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1; P1
Human protein sequence Database
Q9H1E3
Mouse protein sequence database
Q80XU3
Rat protein sequence database
Q9EPJ0
Cellular localization
Nucleus . Chromosome .
Tissue expression
Widely expressed, with highest levels in thyroid gland, prostate and uterus and in fetal liver, thymus and lung.
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