Molecular weight (DA)
75kD
Immunogen
The antiserum was produced against synthesized peptide derived from human NFE2L3. AA range:491-540
Specificity
Nrf3 Polyclonal Antibody detects endogenous levels of Nrf3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. [provided by RefSeq, Mar 2009],
Function
function:Activates erythroid-specific, globin gene expression.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. CNC subfamily.,similarity:Contains 1 bZIP domain.,subunit:Heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE).,tissue specificity:Highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas.,
Protein name
Nuclear factor erythroid 2-related factor 3
Other name
NFE2L3; NRF3; Nuclear factor erythroid 2-related factor 3; NF-E2-related factor 3; NFE2-related factor 3; Nuclear factor; erythroid derived 2, like 3
Human protein sequence Database
Q9Y4A8
Mouse protein sequence database
Q9WTM4
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas.
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