hnRNP A2/B1 Polyclonal Antibody

Polyclonal antibody

Specification

BYab-01799

50UL $180 100UL $255
Delivery： In Stock

Product introduction Experimental scheme Citation Related products

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Host

Reactiveness

Use

Molecular weight (DA)

36+38kD

Immunogen

The antiserum was produced against synthesized peptide derived from human hnRNP A2/B1. AA range:1-50

Specificity

hnRNP A2/B1 Polyclonal Antibody detects endogenous levels of hnRNP A2/B1 protein.

Source

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Dilution rate

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Purification process (Immunogen)

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Background

This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008],

Function

function:Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleous.,similarity:Contains 2 RRM (RNA recognition motif) domains.,subcellular location:Component of ribonucleosomes. Predominantly nucleoplasmic, however isoform A2 is also found in the cytoplasm of cells in some tissues. Not found in the nucleolus.,subunit:Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRNPA1, HNRNPA2B1, HNRPA3, HNRNPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRNPR, HNRNPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA

Gene Name

HNRNPA2B1

Protein name

Heterogeneous nuclear ribonucleoproteins A2/B1

Abbreviation

hnRNP A2/B1

Other name

HNRNPA2B1; HNRPA2B1; Heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2/B1

Fields

>>Amyotrophic lateral sclerosis

Human gene ID

3181

Human protein sequence Database

P22626

Mouse gene ID

100000000

Mouse protein sequence database

O88569

Rat gene ID

Rat protein sequence database

Cellular localization

Nucleus . Nucleus, nucleoplasm . Cytoplasm . Cytoplasmic granule . Secreted, extracellular exosome . Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661). Component of ribonucleosomes (PubMed:17289661). Not found in the nucleolus (PubMed:17289661). Found in exosomes following sumoylation (PubMed:24356509). .; [Isoform A2]: Nucleus . Cytoplasm . Predominantly nucleoplasmic, however is also found in the cytoplasm of cells in some tissues (PubMed:17289661). .

Tissue expression

Brain,Cajal-Retzius cell,Cervix carcinoma,Epitheliu

Storage

-20°C/1 year

Experimental scheme>

Procedure

hnRNP A2/B1 Polyclonal Antibody

BYab-01799

Product introduction>

Host

Reactiveness

Use

Molecular weight (DA)

Immunogen

Specificity

Source

Formulation

Dilution rate

Purification process (Immunogen)

Concentration

Background

Function

Gene Name

Protein name

Abbreviation

Other name

Fields

Human gene ID

Human protein sequence Database

Mouse gene ID

Mouse protein sequence database

Rat gene ID

Rat protein sequence database

Cellular localization

Tissue expression

Storage

Experimental scheme>

Citation(0)>

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hnRNP A2/B1 Polyclonal Antibody

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