Molecular weight (DA)
114kD
Immunogen
The antiserum was produced against synthesized peptide derived from human IARS2. AA range:71-120
Specificity
IARS2 Polyclonal Antibody detects endogenous levels of IARS2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of isoleucine-tRNA synthetase exist, a cytoplasmic form and a mitochondrial form. This gene encodes the mitochondrial isoleucine-tRNA synthetase which belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Dec 2014],
Function
catalytic activity:ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).,similarity:Belongs to the class-I aminoacyl-tRNA synthetase family.,
Protein name
Isoleucine--tRNA ligase mitochondrial
Other name
IARS2; Isoleucine--tRNA ligase; mitochondrial; Isoleucyl-tRNA synthetase; IleRS
Fields
>>Aminoacyl-tRNA biosynthesis
Human protein sequence Database
Q9NSE4
Mouse protein sequence database
Q8BIJ6
Rat protein sequence database
Cellular localization
Mitochondrion matrix .
Tissue expression
Brain,Epithelium,Liver,Placenta,Skin,
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