Molecular weight (DA)
60kD
Immunogen
The antiserum was produced against synthesized peptide derived from human HNRPLL. AA range:241-290
Specificity
hnRNP LL Polyclonal Antibody detects endogenous levels of hnRNP LL protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
heterogeneous nuclear ribonucleoprotein L like(HNRNPLL) Homo sapiens HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008],
Function
function:May bind RNA and play a role in mRNA processing.,similarity:Contains 3 RRM (RNA recognition motif) domains.,tissue specificity:Widely expressed. Detected in bone marrow stroma cells, skeletal muscle, heart, placenta, pancreas, kidney and lung.,
Protein name
Heterogeneous nuclear ribonucleoprotein L-like
Other name
HNRPLL; SRRF; BLOCK24; Heterogeneous nuclear ribonucleoprotein L-like; hnRNPLL; Stromal RNA-regulating factor
Human protein sequence Database
Q8WVV9
Mouse protein sequence database
Q921F4
Rat protein sequence database
Cellular localization
nucleus,membrane,viral nucleocapsid,intracellular ribonucleoprotein complex,
Tissue expression
Widely expressed. Detected in bone marrow stroma cells, skeletal muscle, heart, placenta, pancreas, kidney and lung.
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