Molecular weight (DA)
120kD
Immunogen
The antiserum was produced against synthesized peptide derived from human DDX24. AA range:41-90
Specificity
DDX24 Polyclonal Antibody detects endogenous levels of DDX24 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. [provided by RefSeq, Jul 2008],
Function
function:ATP-dependent RNA helicase .,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the DEAD box helicase family.,similarity:Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,tissue specificity:Ubiquitous. Most abundant in heart and brain, but with lowest levels in thymus and small intestine.,
Protein name
ATP-dependent RNA helicase DDX24
Other name
DDX24; ATP-dependent RNA helicase DDX24; DEAD box protein 24
Human protein sequence Database
Q9GZR7
Mouse protein sequence database
Q9ESV0
Rat protein sequence database
Cellular localization
nucleolus,membrane,
Tissue expression
Ubiquitous. Most abundant in heart and brain, but with lowest levels in thymus and small intestine.
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