Molecular weight (DA)
44kD
Immunogen
The antiserum was produced against synthesized peptide derived from human REQU. AA range:151-200
Specificity
DPF2 Polyclonal Antibody detects endogenous levels of DPF2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors. [provided by RefSeq, Jul 2008],
Function
function:May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells.,similarity:Belongs to the requiem/DPF family.,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 2 PHD-type zinc fingers.,subcellular location:30% nuclear. 70% cytoplasmic.,tissue specificity:Ubiquitous.,
Protein name
Zinc finger protein ubi-d4
Other name
DPF2; BAF45D; REQ; UBID4; Zinc finger protein ubi-d4; Apoptosis response zinc finger protein; BRG1-associated factor 45D; BAF45D; D4; zinc and double PHD fingers family 2; Protein requiem
Human protein sequence Database
Q92785
Mouse protein sequence database
Q61103
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm .
Tissue expression
Ubiquitous.
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