Immunogen
The antiserum was produced against synthesized peptide derived from human GCN2. AA range:865-914
Specificity
GCN2 Polyclonal Antibody detects endogenous levels of GCN2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:Kinase domain 1 is a degenerate kinase domain.,domain:RWD domain is reported to interact with GCN1L1.,function:Can phosphorylate the alpha subunit of EIF2 and may mediate translational control.,PTM:Autophosphorylated on threonine residues.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.,similarity:Contains 1 RWD domain.,similarity:Contains 2 protein kinase domains.,tissue specificity:Widely expressed.,
Protein name
Eukaryotic translation initiation factor 2-alpha kinase 4
Other name
EIF2AK4; GCN2; KIAA1338; Eukaryotic translation initiation factor 2-alpha kinase 4; GCN2-like protein
Fields
>>Autophagy - animal;>>Protein processing in endoplasmic reticulum;>>Hepatitis C;>>Measles;>>Herpes simplex virus 1 infection
Human protein sequence Database
Q9P2K8
Mouse protein sequence database
Q9QZ05
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Widely expressed (PubMed:10504407). Expressed in lung, smooth muscle cells and macrophages (PubMed:24292273).
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