Immunogen
The antiserum was produced against synthesized peptide derived from human DNA Polymerase zeta. AA range:231-280
Specificity
DNA pol ζ Polyclonal Antibody detects endogenous levels of DNA pol ζ protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,domain:Its C-terminal part could serve as the catalytic domain during nucleotide polymerization, while its N-terminal part could provide sites for protein-protein interactions with other factors during translesion DNA synthesis.,similarity:Belongs to the DNA polymerase type-B family.,subunit:Interacts with REV7.,tissue specificity:Ubiquitously expressed.,
Function
catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,domain:Its C-terminal part could serve as the catalytic domain during nucleotide polymerization, while its N-terminal part could provide sites for protein-protein interactions with other factors during translesion DNA synthesis.,similarity:Belongs to the DNA polymerase type-B family.,subunit:Interacts with REV7.,tissue specificity:Ubiquitously expressed.,
Protein name
DNA polymerase zeta catalytic subunit
Other name
REV3L; POLZ; REV3; DNA polymerase zeta catalytic subunit; Protein reversionless 3-like; REV3-like; hREV3
Fields
>>Platinum drug resistance;>>Fanconi anemia pathway
Human protein sequence Database
O60673
Mouse protein sequence database
Q61493
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Ubiquitously expressed.
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