Molecular weight (DA)
38kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ZDHHC15. AA range:288-337
Specificity
DHHC-15 Polyclonal Antibody detects endogenous levels of DHHC-15 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene belongs to the DHHC palmitoyltransferase family. Mutations in this gene are associated with mental retardatio X-linked type 91 (MRX91). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009],
Function
catalytic activity:Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.,disease:Defects in ZDHHC15 are the cause of mental retardation X-linked type 91 (MRX91) [MIM:300577]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.,domain:The DHHC domain is required for palmitoyltransferase activity.,function:Palmitoyltransferase specific for GAP43 and DLG4/PSD95.,PTM:Autopalmitoylated.,similarity:Belongs to the DHHC palmitoyltransferase family.,similarity:Contains 1 DHHC-type zinc finger.,tissue specificity:Expressed in placenta, liver, lung, kidney, heart and brain.,
Protein name
Palmitoyltransferase ZDHHC15
Other name
ZDHHC15; Palmitoyltransferase ZDHHC15; Zinc finger DHHC domain-containing protein 15; DHHC-15
Human protein sequence Database
Q96MV8
Mouse protein sequence database
Q8BGJ0
Rat protein sequence database
Cellular localization
Golgi apparatus membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic density .
Tissue expression
Expressed in placenta, liver, lung, kidney, heart and brain.
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