Molecular weight (DA)
64kD
Immunogen
The antiserum was produced against synthesized peptide derived from human T3JAM. AA range:251-300
Specificity
T3JAM Polyclonal Antibody detects endogenous levels of T3JAM protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The gene encodes a protein that mediates cell growth by modulating the c-Jun N-terminal kinase signal transduction pathway. The encoded protein may also interact with a large multi-protein assembly containing the phosphatase 2A catalytic subunit. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],
Function
function:May function as an adapter molecule that regulates TRAF3-mediated JNK activation.,subunit:Binds to the isoleucine zipper of TRAF3 via its coiled-coil domain.,
Protein name
TRAF3-interacting JNK-activating modulator
Other name
TRAF3IP3; T3JAM; TRAF3-interacting JNK-activating modulator; TRAF3-interacting protein 3
Human protein sequence Database
Q9Y228
Mouse protein sequence database
Q8C0G2
Rat protein sequence database
Cellular localization
Cell membrane . Golgi apparatus membrane ; Single-pass type IV membrane protein . Lysosome membrane . Mitochondrion outer membrane . Accumulates on the mitochondria after virus infection. .
Tissue expression
Blood,Lung adenocarcinoma,