Molecular weight (DA)
27kD
Immunogen
The antiserum was produced against synthesized peptide derived from human THOC4. AA range:121-170
Specificity
ALY Polyclonal Antibody detects endogenous levels of ALY protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins. [provided by RefSeq, Jul 2008],
Function
disease:Antibodies against THOC4 are found in sera of patients with systemic lupus erythematosus (SLE).,function:Acts as chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation. Plays a role in mRNA processing and export. May function as scaffold that mediates interactions between proteins and/or RNA. Integral part of the THO/TREX complex that is recruited to transcribed genes and travels with the RNA polymerase during elongation. Is part of the exon junction complex that remains associated with spliced mRNA and plays an important role in mRNA export and nonsense-mediated RNA decay. Directs mRNA derived from Herpes simplex virus intron-less genes to the NXF1-mediated export pathway.,PTM:Arg-50 and Arg-204 are dimethylated, probably to asymmetric dimethylarginine.,PTM:Phosphorylated upo
Protein name
THO complex subunit 4
Other name
ALYREF; ALY; BEF; THOC4; THO complex subunit 4; Tho4; Ally of AML-1 and LEF-1; Aly/REF export factor; Transcriptional coactivator Aly/REF; bZIP-enhancing factor BEF
Fields
>>Nucleocytoplasmic transport;>>mRNA surveillance pathway;>>Spliceosome;>>Amyotrophic lateral sclerosis;>>Herpes simplex virus 1 infection
Human protein sequence Database
Q86V81
Mouse protein sequence database
O08583
Rat protein sequence database
Cellular localization
Nucleus . Nucleus speckle . Cytoplasm . Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and DDX39B in the nucleus and nuclear speckles. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA (PubMed:19324961). Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur (PubMed:23826332). .
Tissue expression
Expressed in a wide variety of cancer types.
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