Molecular weight (DA)
15-17kD
Immunogen
The antiserum was produced against synthesized peptide derived from human HMG17 around the phosphorylation site of Ser29. AA range:1-50
Specificity
Phospho-HMG-17 (S29) Polyclonal Antibody detects endogenous levels of HMG-17 protein only when phosphorylated at S29.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
high mobility group nucleosomal binding domain 2(HMGN2) Homo sapiens The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi. [provided by RefSeq, Oct 2014],
Function
function:Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation.,mass spectrometry: PubMed:10739259,PTM:Phosphorylation favors cytoplasmic localization.,similarity:Belongs to the HMGN family.,subcellular location:Cytoplasmic enrichment upon phosphorylation.,
Protein name
Non-histone chromosomal protein HMG-17
Other name
HMGN2; HMG17; Non-histone chromosomal protein HMG-17; High mobility group nucleosome-binding domain-containing protein 2
Human protein sequence Database
P05204
Mouse protein sequence database
P09602
Rat protein sequence database
P18437
Cellular localization
Nucleus . Cytoplasm . Cytoplasmic enrichment upon phosphorylation.
Tissue expression
Brain,Colon,Eye,Lung,Lymph,Mammary gland,Muscle,Peripheral
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