Molecular weight (DA)
17kD
Immunogen
The antiserum was produced against synthesized peptide derived from human IFN-gamma. AA range:20-69
Specificity
IFN-γ Polyclonal Antibody detects endogenous levels of IFN-γ protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015],
Function
disease:In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.,function:Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.,online information:Interferon ga
Protein name
Interferon gamma
Other name
IFNG; Interferon gamma; IFN-gamma; Immune interferon
Fields
>>Proteasome;>>Cytokine-cytokine receptor interaction;>>HIF-1 signaling pathway;>>Necroptosis;>>TGF-beta signaling pathway;>>Osteoclast differentiation;>>Antigen processing and presentation;>>JAK-STAT signaling pathway;>>Natural killer cell mediated cytotoxicity;>>IL-17 signaling pathway;>>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>T cell receptor signaling pathway;>>Type I diabetes mellitus;>>Leishmaniasis;>>Chagas disease;>>African trypanosomiasis;>>Malaria;>>Toxoplasmosis;>>Amoebiasis;>>Tuberculosis;>>Hepatitis C;>>Influenza A;>>Herpes simplex virus 1 infection;>>Pathways in cancer;>>PD-L1 expression and PD-1 checkpoint pathway in cancer;>>Inflammatory bowel disease;>>Systemic lupus erythematosus;>>Rheumatoid arthritis;>>Allograft rejection;>>Graft-versus-host disease;>>Fluid shear stress and atherosclerosis
Human protein sequence Database
P01579
Mouse protein sequence database
P01580
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Released primarily from activated T lymphocytes.
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