Molecular weight (DA)
120kD
Immunogen
Synthesized acetyl-peptide of Acetyl-EPAS-1 (K385)
Specificity
Acetyl-EPAS-1 (K385) Polyclonal Antibody detects endogenous levels of Acetyl-EPAS-1 (K385)
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000, ELISA 1:10000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
endothelial PAS domain protein 1(EPAS1) Homo sapiens This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. [provided by RefSeq, Nov 2009],
Function
disease:Defects in EPAS1 are the cause of erythrocytosis familial type 4 (ECYT4) [MIM:611783]. ECYT4 is an autosomal dominant disorder characterized by increased serum red blood cell mass, elevated hemoglobin concentration and hematocrit, and normal platelet and leukocyte counts.,function:Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300
Gene Name
EPAS1 BHLHE73 HIF2A MOP2 PASD2
Protein name
Acetyl-EPAS-1 (K385)
Other name
endothelial PAS domain protein 1
Fields
>>Pathways in cancer;>>Renal cell carcinoma
Human protein sequence Database
Q99814
Mouse protein sequence database
P97481
Rat protein sequence database
Q9JHS1
Cellular localization
Nucleus . Nucleus speckle . Colocalizes with HIF3A in the nucleus and speckles. .
Tissue expression
Expressed in most tissues, with highest levels in placenta, lung and heart. Selectively expressed in endothelial cells.
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