Molecular weight (DA)
36kD
Immunogen
Synthetic peptide from human protein at AA range: 240-287
Specificity
The antibody detects endogenous TMEPAI
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000, ELISA 1:10000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],
Function
domain:The WW-binding motifs mediate interaction with NEDD4.,induction:By androgen.,similarity:Belongs to the PMEPA1 family.,subunit:Interacts with the WW domains of NEDD4.,tissue specificity:Highest expression in prostate. Also expressed in ovary.,
Gene Name
PMEPA1 STAG1 TMEPAI
Other name
Transmembrane prostate androgen-induced protein (Solid tumor-associated 1 protein)
Human protein sequence Database
Q969W9
Mouse protein sequence database
Q9D7R2
Rat protein sequence database
Cellular localization
Early endosome membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
Tissue expression
Highest expression in prostate. Also expressed in ovary.
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