Immunogen
The antiserum was produced against synthesized peptide derived from human RAD54B. AA range:241-290
Specificity
Rad54B Polyclonal Antibody detects endogenous levels of Rad54B protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The RAD54 homolog B encoded by RAD54B belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer.
Function
M phase, double-strand break repair via homologous recombination, recombinational repair, DNA metabolic process,DNA repair, double-strand break repair, DNA recombination, mitotic recombination, response to DNA damage stimulus,cell cycle, meiosis, meiosis I, reciprocal meiotic recombination, response to radiation, response to abiotic stimulus,response to ionizing radiation, cell cycle process, cell cycle phase, cellular response to stress, response to drug,regulation of transcription, meiotic cell cycle, M phase of meiotic cell cycle,
Protein name
DNA repair and recombination protein RAD54B
Other name
RAD54B; DNA repair and recombination protein RAD54B; RAD54 homolog B
Fields
>>Homologous recombination
Human protein sequence Database
Q9Y620
Mouse protein sequence database
Q6PFE3
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Abundantly expressed in testis and spleen. Relatively low levels observed in thymus, prostate, ovary and colon.
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