Molecular weight (DA)
69kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GNL1. AA range:61-110
Specificity
GNL1 Polyclonal Antibody detects endogenous levels of GNL1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The GNL1 gene, identified in the human major histocompatibility complex class I region, shows a high degree of similarity with its mouse counterpart. The GNL1 gene is located less than 2 kb centromeric to HLA-E, in the same transcriptional orientation. GNL1 is telomeric to HLA-B and HLA-C. [provided by RefSeq, Jul 2008],
Function
domain:In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.,function:Possible regulatory or functional link with the histocompatibility cluster.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the MMR1/HSR1 GTP-binding protein family.,
Protein name
Guanine nucleotide-binding protein-like 1
Other name
GNL1; HSR1; Guanine nucleotide-binding protein-like 1; GTP-binding protein HSR1
Human protein sequence Database
P36915
Mouse protein sequence database
P36916
Rat protein sequence database
Q6MG06
Cellular localization
extracellular space,nucleus,
Tissue expression
Cervix,Muscle,Peripheral blood leukocyte,Skin,T-cell,
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