Molecular weight (DA)
30kD
Immunogen
The antiserum was produced against synthesized peptide derived from human HCC1. AA range:147-196
Specificity
CIP29 Polyclonal Antibody detects endogenous levels of CIP29 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that is upregulated in response to various cytokines. The encoded protein may play a role in cell cycle progression. A translocation between this gene and the myeloid/lymphoid leukemia gene, resulting in expression of a chimeric protein, has been associated with acute myelomonocytic leukemia. Pseudogenes exist on chromosomes 7 and 8. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009],
Function
transcription, regulation of transcription, DNA-dependent, regulation of translation, posttranscriptional regulation of gene expression, regulation of cellular protein metabolic process, regulation of transcription, regulation of RNA metabolic process,
Protein name
SAP domain-containing ribonucleoprotein
Other name
SARNP; HCC1; HSPC316; SAP domain-containing ribonucleoprotein; Cytokine-induced protein of 29 kDa; Nuclear protein Hcc-1; Proliferation-associated cytokine-inducible protein CIP29
Human protein sequence Database
P82979
Mouse protein sequence database
Q9D1J3
Rat protein sequence database
Q498U4
Cellular localization
Nucleus. Nucleus speckle.
Tissue expression
Low expression in spleen, liver, pancreas, testis, thymus, heart, and kidney. Increased levels are seen in hepatocellular carcinoma and pancreatic adenocarcinoma.
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