Molecular weight (DA)
130kD
Immunogen
The antiserum was produced against synthesized peptide derived from human PKP4. AA range:185-234
Specificity
Plakophilin 4 Polyclonal Antibody detects endogenous levels of Plakophilin 4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015],
Function
function:May play a role in junctional plaques.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the beta-catenin family.,similarity:Contains 9 ARM repeats.,subcellular location:Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells.,subunit:Interacts with PDZD2.,
Protein name
Plakophilin-4
Abbreviation
Plakophilin 4
Other name
PKP4; Plakophilin-4; p0071
Human protein sequence Database
Q99569
Mouse protein sequence database
Q68FH0
Rat protein sequence database
Cellular localization
Cell junction, desmosome . Cytoplasm, cytoskeleton, spindle . Midbody . Cell membrane ; Peripheral membrane protein . Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis. Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells.
Tissue expression
Expressed in salivary glands (at protein level) (PubMed:30479852). Expressed in arrector pili muscle (at protein level) (PubMed:29034528).
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