Molecular weight (DA)
85kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CDH11. AA range:421-470
Specificity
OB-cadherin Polyclonal Antibody detects endogenous levels of OB-cadherin protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008],
Function
function:Cadherins are calcium dependent cell adhesion proteins.,function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.,similarity:Contains 5 cadherin domains.,tissue specificity:Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.,
Other name
CDH11; Cadherin-11; OSF-4; Osteoblast cadherin; OB-cadherin
Human protein sequence Database
P55287
Mouse protein sequence database
P55288
Rat protein sequence database
Cellular localization
Cell membrane; Single-pass type I membrane protein.
Tissue expression
Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.
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