Molecular weight (DA)
140kD
Immunogen
The antiserum was produced against synthesized peptide derived from human DSG2. AA range:401-450
Specificity
Dsg2 Polyclonal Antibody detects endogenous levels of Dsg2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq, Jan 2016],
Function
disease:Defects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia 10 (ARVD10) [MIM:610193]; also known as arrhythmogenic right ventricular cardiomyopathy 10 (ARVC10). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.,domain:Calcium may be bound by the cadherin-like repeats .,function:Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.,similarity:Contains 4 cadherin domains.,tissue specificity:All of the tissues tested and carcinomas.,
Protein name
Desmoglein-2
Other name
DSG2; CDHF5; Desmoglein-2; Cadherin family member 5; HDGC
Fields
>>Arrhythmogenic right ventricular cardiomyopathy
Human protein sequence Database
Q14126
Mouse protein sequence database
O55111
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type I membrane protein. Cell junction, desmosome.
Tissue expression
All of the tissues tested and carcinomas.
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