Immunogen
The antiserum was produced against synthesized peptide derived from human GJA3. AA range:151-200
Specificity
Connexin 46 Polyclonal Antibody detects endogenous levels of Connexin 46 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:100-500;IF/ICC 1:100-500;ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a connexin and is a component of lens fiber gap junctions. Defects in this gene are a cause of zonular pulverulent cataract type 3 (CZP3). [provided by RefSeq, Jan 2010],
Function
disease:Defects in GJA3 are the cause of zonular pulverulent cataract type 3 (CZP3) [MIM:601885]. CZP3 is a form of autosomal dominant congenital cataract.,function:One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.,similarity:Belongs to the connexin family. Alpha-type (group II) subfamily.,subunit:A connexon is composed of a hexamer of connexins. This particular connexin is a component of lens fiber gap junctions, can form both junctional and non-junctional ("hemi-") channels.,
Protein name
Gap junction alpha-3 protein
Other name
GJA3; Gap junction alpha-3 protein; Connexin-46; Cx46
Human protein sequence Database
Q9Y6H8
Mouse protein sequence database
Q64448
Rat protein sequence database
P29414
Cellular localization
Cell membrane ; Multi-pass membrane protein . Cell junction, gap junction .
Tissue expression
Lens fibers,
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