Molecular weight (DA)
82kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Catenin-gamma. AA range:696-745
Specificity
Catenin-γ Polyclonal Antibody detects endogenous levels of Catenin-γ protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008],
Function
disease:Defects in JUP are the cause of familial arrhythmogenic right ventricular dysplasia type 12 (ARVD12) [MIM:611528]; also called arrhythmogenic right ventricular cardiomyopathy type 12 (ARVC12). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.,disease:Defects in JUP are the cause of Naxos disease (NXD) [MIM:601214]. NXD is an autosomal recessive disorder combining diffuse non-epidermolytic palmoplantar keratoderma with arrhythmogenic right ventricular dysplasia/cardiomyopathy and woolly hair.,function:Common junctional plaque protein. The membrane-assoc
Protein name
Junction plakoglobin
Other name
JUP; CTNNG; DP3; Junction plakoglobin; Catenin gamma; Desmoplakin III; Desmoplakin-3
Fields
>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Acute myeloid leukemia;>>Gastric cancer;>>Arrhythmogenic right ventricular cardiomyopathy
Human protein sequence Database
P14923
Mouse protein sequence database
Q02257
Rat protein sequence database
Q6P0K8
Cellular localization
Cell junction, adherens junction . Cell junction, desmosome . Cytoplasm, cytoskeleton . Membrane ; Peripheral membrane protein . Cytoplasmic in a soluble and membrane-associated form.
Tissue expression
Cervix carcinoma,Epidermal carcinoma,Epithelium,Leukocyte,Lung,Lung carcinoma,Place
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