Molecular weight (DA)
9kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CKS1. AA range:10-59
Specificity
Cks1 Polyclonal Antibody detects endogenous levels of Cks1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. [provided by RefSeq, Sep 2008],
Function
function:Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.,similarity:Belongs to the CKS family.,subunit:Forms a homohexamer that can probably bind six kinase subunits.,
Protein name
Cyclin-dependent kinases regulatory subunit 1
Other name
CKS1B; CKS1; PNAS-143; PNAS-16; Cyclin-dependent kinases regulatory subunit 1; CKS-1
Fields
>>Pathways in cancer;>>Small cell lung cancer
Human protein sequence Database
P61024
Mouse protein sequence database
P61025
Rat protein sequence database
Cellular localization
cyclin-dependent protein kinase holoenzyme complex,nucleoplasm,SCF ubiquitin ligase complex,
Tissue expression
Brain,Muscle,Promyelocytic leukemia,Prostate,Tongue,
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