Molecular weight (DA)
90kD
Immunogen
Synthesized peptide derived from the Internal region of human TRPV3.
Specificity
TRPV3 Polyclonal Antibody detects endogenous levels of TRPV3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
transient receptor potential cation channel subfamily V member 3(TRPV3) Homo sapiens This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012],
Function
function:Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity.,similarity:Belongs to the transient receptor family. TrpV subfamily.,similarity:Contains 3 ANK repeats.,subunit:May form a heteromeric channel with TRPV1. Interacts with TRPV1.,tissue specificity:Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion (at protein level).,
Protein name
Transient receptor potential cation channel subfamily V member 3
Other name
TRPV3; Transient receptor potential cation channel subfamily V member 3; TrpV3; Vanilloid receptor-like 3; VRL-3
Fields
>>Inflammatory mediator regulation of TRP channels
Human protein sequence Database
Q8NET8
Mouse protein sequence database
Q8K424
Rat protein sequence database
Cellular localization
Membrane; Multi-pass membrane protein.
Tissue expression
Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion (at protein level). Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles (at protein level).
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