Molecular weight (DA)
33kD
Immunogen
The antiserum was produced against synthesized peptide derived from human UCP3. AA range:259-308
Specificity
UCP3 Polyclonal Antibody detects endogenous levels of UCP3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria.
Function
disease:Defects in UCP3 may be involved in severe obesity [MIM:601665].,function:UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.,similarity:Belongs to the mitochondrial carrier family.,similarity:Contains 3 Solcar repeats.,tissue specificity:Only in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal muscles.,
Protein name
Mitochondrial uncoupling protein 3
Other name
UCP3; SLC25A9; Mitochondrial uncoupling protein 3; UCP 3; Solute carrier family 25 member 9
Human protein sequence Database
P55916
Mouse protein sequence database
P56501
Rat protein sequence database
P56499
Cellular localization
Mitochondrion inner membrane ; Multi-pass membrane protein .
Tissue expression
Only in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal muscles.
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