Molecular weight (DA)
80kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SLCO1A2. AA range:251-300
Specificity
OATP1 Polyclonal Antibody detects endogenous levels of OATP1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008],
Function
function:Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids.,similarity:Belongs to the organo anion transporter (TC 2.A.60) family.,
Protein name
Solute carrier organic anion transporter family member 1A2
Other name
SLCO1A2; OATP; OATP1; OATP1A2; SLC21A3; Solute carrier organic anion transporter family member 1A2; OATP-A; Organic anion-transporting polypeptide 1; OATP-1; Sodium-independent organic anion transporter; Solute carrier family 21 member 3
Human protein sequence Database
P46721
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Brain,Liver,Teratocarcinoma,
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