Molecular weight (DA)
100kD
Immunogen
The antiserum was produced against synthesized peptide derived from human mGluR4. AA range:851-900
Specificity
mGluR-4 Polyclonal Antibody detects endogenous levels of mGluR-4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
glutamate metabotropic receptor 4(GRM4) Homo sapiens L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this
Function
function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.,similarity:Belongs to the G-protein coupled receptor 3 family.,subunit:Interacts with PICK1.,tissue specificity:Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver.,
Protein name
Metabotropic glutamate receptor 4
Other name
GRM4; GPRC1D; MGLUR4; Metabotropic glutamate receptor 4; mGluR4
Fields
>>Phospholipase D signaling pathway;>>Neuroactive ligand-receptor interaction;>>Glutamatergic synapse;>>Taste transduction
Human protein sequence Database
Q14833
Mouse protein sequence database
Q68EF4
Rat protein sequence database
P31423
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver.
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