Molecular weight (DA)
48kD
Immunogen
The antiserum was produced against synthesized peptide derived from mouse Kir5.1. AA range:369-418
Specificity
KIR5.1 Polyclonal Antibody detects endogenous levels of KIR5.1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which tends to allow potassium to flow into rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may function in fluid and pH balance regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014],
Function
function:Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance.,similarity:Belongs to the inward rectifier-type potassium channel family.,subunit:Seems to form heterodimer with Kir4.1/KCNJ10 or Kir2.1/KCNJ2.,tissue specificity:Highly expressed in kidney, pancreas and thyroid gland.,
Protein name
Inward rectifier potassium channel 16
Other name
KCNJ16; Inward rectifier potassium channel 16; Inward rectifier K(+) channel Kir5.1; Potassium channel; inwardly rectifying subfamily J member 16
Fields
>>Gastric acid secretion
Human protein sequence Database
Q9NPI9
Mouse protein sequence database
Q9Z307
Rat protein sequence database
P52191
Cellular localization
Membrane ; Multi-pass membrane protein. Basolateral cell membrane . In kidney distal convoluted tubules, located in the basolateral membrane in the presence of KCNJ10. .
Tissue expression
Widely expressed, with highest levels in adult and fetal kidney (at protein level). In the kidney, expressed in the proximal and distal convoluted tubules, but not in glomeruli nor collecting ducts.
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