Molecular weight (DA)
102kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CNGB1. AA range:571-620
Specificity
CNG-1β Polyclonal Antibody detects endogenous levels of CNG-1β protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
In humans, the rod photoreceptor cGMP-gated cation channel helps regulate ion flow into the rod photoreceptor outer segment in response to light-induced alteration of the levels of intracellular cGMP. This channel consists of two subunits, alpha and beta, with the protein encoded by this gene representing the beta subunit. Defects in this gene are a cause of cause of retinitis pigmentosa type 45. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013],
Function
disease:Defects in CNGB1 are the cause of retinitis pigmentosa type 25 (RP25) [MIM:268000]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.,similarity:Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.,similarity:Contains 1 cyclic nucleotide-binding domain.,subunit:Heterooligomeric complex with CNGA1.,
Protein name
Cyclic nucleotide-gated cation channel beta-1
Other name
CNGB1; CNCG2; CNCG3L; CNCG4; RCNC2; Cyclic nucleotide-gated cation channel beta-1; Cyclic nucleotide-gated cation channel 4; CNG channel 4; CNG-4; CNG4; Cyclic nucleotide-gated cation channel gamma; Cyclic nucleotide-gated cation channel mo
Fields
>>cGMP-PKG signaling pathway;>>cAMP signaling pathway;>>Olfactory transduction;>>Phototransduction
Human protein sequence Database
Q14028
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Membrane; Multi-pass membrane protein.
Tissue expression
Retina,
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