Molecular weight (DA)
29kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 120-200
Specificity
CD82 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
function:Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.,similarity:Belongs to the tetraspanin (TM4SF) family.,subunit:Interacts directly with IGSF8.,tissue specificity:Lymphoid specific.,
Gene Name
CD82 KAI1 SAR2 ST6 TSPAN27
Protein name
CD82 antigen (C33 antigen) (IA4) (Inducible membrane protein R2) (Metastasis suppressor Kangai-1) (Suppressor of tumorigenicity 6 protein) (Tetraspanin-27) (Tspan-27) (CD antigen CD82)
Fields
>>p53 signaling pathway
Human protein sequence Database
P27701
Mouse protein sequence database
P40237
Rat protein sequence database
O70352
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Lymphoid specific.
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