Molecular weight (DA)
18kD
Immunogen
The antiserum was produced against synthesized peptide derived from human RAP2B. AA range:98-147
Specificity
Rap 2B Polyclonal Antibody detects endogenous levels of Rap 2B protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq, Jul 2008],
Function
domain:The effector domain mediates the interaction with RUNDC3A.,similarity:Belongs to the small GTPase superfamily. Ras family.,subunit:Interacts with PLCE1. Interacts with SGSM1, SGSM2 and SGSM3. The GTP-bound form of RAP2B interacts with RUNDC3A.,
Protein name
Ras-related protein Rap-2b
Other name
RAP2B; Ras-related protein Rap-2b
Human protein sequence Database
P61225
Mouse protein sequence database
P61226
Rat protein sequence database
P61227
Cellular localization
Recycling endosome membrane ; Lipid-anchor ; Cytoplasmic side . Associated with red blood cells-released vesicles.
Tissue expression
Expressed in red blood cells (at protein level).
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