Molecular weight (DA)
68kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GBP1. AA range:71-120
Specificity
GBP1 Polyclonal Antibody detects endogenous levels of GBP1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008],
Function
function:Binds GTP, GDP and GMP.,induction:By interferon gamma during macrophage activation.,similarity:Belongs to the GBP family.,
Protein name
Interferon-induced guanylate-binding protein 1
Other name
GBP1; Interferon-induced guanylate-binding protein 1; GTP-binding protein 1; GBP-1; HuGBP-1; Guanine nucleotide-binding protein 1
Fields
>>NOD-like receptor signaling pathway
Human protein sequence Database
P32455
Mouse protein sequence database
Q01514
Rat protein sequence database
Cellular localization
Cytoplasm . Golgi apparatus membrane; Lipid-anchor ; Cytoplasmic side. Cell membrane . Secreted . Cytoplasmic vesicle . Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of IFNG induction. Golgi membrane localization requires isoprenylation and the presence of another IFNG-induced factor.
Tissue expression
Placenta,Spleen,Uterus,
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