Immunogen
Synthesized peptide derived from ARHGAP23 . at AA range: 470-550
Specificity
ARHGAP23 Polyclonal Antibody detects endogenous levels of ARHGAP23 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins, such as ARHGAP23, inactivate RHO family proteins by stimulating their hydrolysis of GTP (Katoh and Katoh, 2004 [PubMed 15254754]).[supplied by OMIM, Mar 2008],
Function
function:GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 Rho-GAP domain.,tissue specificity:Expressed in placenta, prostate, hippocampus and brain medulla. Also expressed in brain tumor, salivary gland tumor, head and neck tumor.,
Protein name
Rho GTPase-activating protein 23
Other name
ARHGAP23; KIAA1501; Rho GTPase-activating protein 23; Rho-type GTPase-activating protein 23
Human protein sequence Database
Q9P227
Mouse protein sequence database
Q69ZH9
Rat protein sequence database
Cellular localization
cytosol,extracellular exosome,
Tissue expression
Expressed in placenta, prostate, hippocampus and brain medulla. Also expressed in brain tumor, salivary gland tumor, head and neck tumor.
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