Molecular weight (DA)
110kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ARHGAP11A. AA range:471-520
Specificity
ARHGAP11A Polyclonal Antibody detects endogenous levels of ARHGAP11A protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the Rho GTPase activating protein family. In response to DNA damage, the encoded protein interacts with the p53 tumor suppressor protein and stimulates its tetramerization, which results in cell-cycle arrest and apoptosis. A chromosomal deletion that includes this gene is one cause of Prader-Willi syndrome, and an intronic variant of this gene may be associated with sleep duration in children. This gene is highly expressed in colon cancers and in a human basal-like breast cancer cell line. [provided by RefSeq, Sep 2016],
Function
similarity:Contains 1 Rho-GAP domain.,
Protein name
Rho GTPase-activating protein 11A
Other name
ARHGAP11A; KIAA0013; Rho GTPase-activating protein 11A; Rho-type GTPase-activating protein 11A
Human protein sequence Database
Q6P4F7
Mouse protein sequence database
Q80Y19
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Bone marrow,Epithelium,Eye,Testis,Uterus,
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